Senior Director, Cancer Biology and Targeted Therapies

Full Time
Posted 3 weeks ago

Position Summary
This Senior Director position will play a critical role in helping to build and expand the ArriVent portfolio by (1) scientifically evaluating clinical and non-clinical stage assets for licensing including design and interpretation of nonclinical studies with CROs to confirm MOA and benchmark to competitors, (2) develop Target Candidate Profiles for Research collaboration programs and monitor Research program progress, (3) serve as the project team leader for non-clinical stage programs as they advance towards IND, (4) provide scientific input into Development plans for portfolio programs including conducting nonclinical studies to support indication selection and combinations.  This position will report into the Head of R&D.

Responsibilities Include:

  • Partner with the Business Development team and consultants in Chemistry, Toxicology and Pharmacology to identify suitable Research/pre-IND stage molecules for potential licensing.
  • Aid in advancing partnering opportunities through the deal funnel by rigorously assessing the science behind the target and the qualities of the lead molecule versus competitor molecules.
  • Contribute to the identification of biotechs with innovative therapies for Research stage partnerships and oversee projects
  • Design and execute Research plans through CROs to demonstrate MOA for IND and to support the clinical development plan post-IND
  • Serve as the Team leader for Research stage programs as they advance to IND
  • Author scientific background section of regulatory documents
  • Attend scientific conferences to stay abreast of new developments
  • Maintain presence in professional industry networks and represent the company in the industry associations

Experience & Qualifications

  • Advanced scientific degree (PhD) in Cancer Biology or related discipline
  • A minimum of 10 years of experience beyond PhD including at least 7 years of Pharmaceutical Research experience
  • Experience in small molecules for oncology indications including non-clinical pharmacology
  • Experience working with BD and consultants to evaluate small molecule drug candidates for licensing
  • Experience in defining Target Candidate Profiles and competitor benchmarking
  • Strong experience in defining and executing Research strategy for oncology programs
  • Extensive understanding of in vitro and in vivo systems for demonstrating MOA
  • Experience in assembling IND packages including authoring scientific sections
  • Experience overseeing CROs and contractors
  • Ability to work collaboratively with Research partners, consultants and internal team to advance non-clinical and clinical stage programs
  • Strong problem-solving and quantitative skills
  • Excellent written and communication skills
  • Strategic thinker with proven ability to evaluate the strategic implications of business development decisions
  • A strong professional presence with peers
  • West coast location required

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