Careers
Summary of Position
The Director/Senior Director, Clinical Science will provide Clinical Science leadership and direct oversight for ArriVent’s oncology clinical development programs across early- and late-stage development and across both small molecule and large molecule (including antibody-drug conjugate, or ADC) modalities. This is a hands-on role that combines clinical development strategy with direct execution and ownership of critical deliverables. The role leads the planning, implementation, and ongoing scientific interpretation of clinical studies; partners closely with Medical Directors and cross-functional teams; and supports high-quality clinical and regulatory deliverables from IND through registration. The position will also lead and support departmental and clinical initiatives that strengthen program quality and cross-functional execution. This position is ideally based in the San Francisco Bay Area.
Key Responsibilities:
- Provide Clinical Science leadership for oncology programs across early- and late-stage development, spanning both small molecule and large molecule (including ADC) modalities.
- Operate as a hands-on leader who sets clinical strategy while directly driving execution, preparing and reviewing core deliverables, resolving issues, and advancing day-to-day program priorities in a resource-conscious biotechnology environment.
- Lead and contribute to clinical trial design, including first-in-human studies, dose escalation, dose optimization, expansion cohorts, and registrational or pivotal studies, as applicable.
- Lead development of key clinical deliverables, including protocols, clinical study reports (CSRs), investigator’s brochures (IBs), and other clinical development documents, in collaboration with Medical Directors and cross-functional partners.
- Lead ongoing clinical data review and interpretation, integrating efficacy, safety, pharmacokinetic, biomarker, and other translational data in partnership with Clinical Development and cross-functional teams.
- Support development of clinical strategies that inform dose selection, patient selection, study design, and advancement of programs through key development milestones, adapting approaches to the modality and stage of each program.
- Oversee clinical trials to assess study progress, ensure appropriate study conduct and protocol adherence, and lead data evaluation and analyses with Data Management, Biostatistics, and Programming.
- Partner closely with Clinical Development, Clinical Operations, Biostatistics, Data Management, Regulatory, Safety, Translational Medicine, and other functions on small molecule and large molecule development programs.
- Contribute to regulatory interactions and clinical development documents supporting programs from IND through registration, including dossiers, NDAs, safety and annual reports, health authority briefing materials, and responses to regulatory agencies.
- Lead and support departmental and clinical initiatives that improve the quality and content of clinical programs and refine cross-functional processes used to deliver ArriVent’s portfolio.
Qualifications:
Required
- 8+ years of relevant clinical development experience in the biotechnology/pharmaceutical industry, with level determined based on depth and scope of experience.
- Strong clinical development experience in oncology, with significant experience in solid tumors.
- Clinical development experience including direct involvement in the design, conduct, data review, and/or interpretation of clinical trials across modalities.
- Demonstrated clinical development experience in Phase 3 registrational trials.
- Experience designing and/or executing oncology clinical trials and leading clinical data review and interpretation.
- Experience developing protocols, CSRs, IBs, clinical sections of NDAs, health authority briefing packages, regulatory documents, and responses to health authority and IRB requests.
- Demonstrated ability to thrive in a small biotechnology company by moving fluidly between strategy and hands-on execution, working with a high level of independence, and taking direct ownership of deliverables and outcomes.
- Excellent written and oral communication, interpersonal, collaboration, and cross-functional leadership skills.
- Experience with small molecules and antibody-drug conjugates (ADCs) is a plus.
Education:
- PhD, PharmD, or equivalent advanced scientific/clinical degree required.