ArriVent Pharmaceuticals Science
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CandidateCand
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Phase 2Ph2
Phase 3Ph3
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Furmonertinib

Oral, brain penetrant, EGFR mutation selective inhibitor
NSCLC with EGFR Exon 20 insertion mutations

Furmonertinib - Oral, brain penetrant, EGFR mutation selective inhibitor

NSCLC with EGFR Exon 20 insertion mutations
Phase 3Ph 3
Allist logo
NSCLC with other EGFR mutations
NSCLC with other EGFR mutations
Phase 1bPh 1b
Allist logo
NSCLC with HER2 Exon 20 insertion mutations
NSCLC with HER2 Exon 20 insertion mutations
Phase 1bPh 1b
Allist logo

ARR-002

Undisclosed
Solid Tumors

ARR-002 - Undisclosed

Solid Tumors
DiscoveryDisc
AARVIK logo

Furmonertinib

Mutational activation of the epidermal growth factor receptor (EGFR) is a common and early event in the development of non-small cell lung cancer (NSCLC) and confers oncogene dependency on the growth and proliferation of cancer cells. EGFR activating mutations are present in approximately 15% of NSCLC. Patients with NSCLC containing EGFR activating mutations are also particularly prone to the development of brain metastases, with 50% to 60% developing central nervous system (CNS) metastases over the course of their disease. Despite initial clinical response to currently approved EGFR inhibitors, patients with advanced EGFR mutated NSCLC inevitably acquire resistance mechanisms and progress at some point during treatment; therefore, there is the need for more effective, tolerable treatments.

Furmonertinib is an oral, highly brain-penetrant, irreversible pan-EGFR mutant inhibitor discovered and developed in China by our partners Allist Pharmaceuticals to selectively target EGFR activating mutations including atypical EGFR mutations such as EGFR Exon 20 insertions. Furmonertinib also targets HER2 Exon20 insertion mutations present in approximately 1.5% of NSCLC. In a Phase 3 double blind, placebo-controlled study in 1L EGFR mutant NSCLC, furmonertinib has demonstrated superiority over the 1st generation EGFR inhibitor gefitinib. Furmonertinib has also demonstrated encouraging preliminary activity in EGFR Exon 20 insertion mutant NSCLC.

Building on the clinical data collected in China by Allist, ArriVent is studying furmonertinib globally in patients with EGFR mutant and HER2 Exon 20 insertion mutant NSCLC.

ARR-002

We are partnered with Aarvik Therapeutics to advance a novel cancer therapeutic agent. As part of our agreement, Aarvik is responsible for the discovery and preclinical validation of the novel molecule, which is based on their unique modular platform that combines multiple target mechanisms. The ArriVent team will lead development and commercialization of the ARR-002 program.